Effect Identification in Comparative Effectiveness Research

Effect Identification in Comparative Effectiveness Research

The widespread adoption of electronic medical records means there are now vast data resources available for comparative effectiveness research (CER). In concert with conventional randomized controlled trials, CER holds great promise for advancing our understanding of how different therapeutic treatments yield different health outcomes in different settings and with different populations. But in...

Heterogeneity in Treatment Effect and Comparative Effectiveness Research.

The ultimate goal of comparative effectiveness research (CER) is to develop and disseminate evidence-based information about which interventions are most effective for which patients under what circumstances. To achieve this goal it is crucial that researchers in methodology development find appropriate methods for detecting the presence and sources of heterogeneity in treatment effect (HTE). C...

Methods in comparative effectiveness research.

Comparative effectiveness research (CER) seeks to assist consumers, clinicians, purchasers, and policy makers to make informed decisions to improve health care at both the individual and population levels. CER includes evidence generation and evidence synthesis. Randomized controlled trials are central to CER because of the lack of selection bias, with the recent development of adaptive and pra...

CEPAC and comparative effectiveness research.

Comparative Effectiveness Research in Pediatric Infectious Diseases.

Comparative-effectiveness research (CER) is a hot topic. There are several definitions for CER, but the Institute ofMedicine defines CER as “the generation and synthesis of evidence that compares the benefits and harms of alternative methods to prevent, diagnose, treat andmonitor a clinical condition or to improve the delivery of care” [1]. Comparative-effectiveness research focuses more on eff...